Synthesis of probes for the active site of leucine dehydrogenase

Authors
Sutherland, A Willis, CL
Citation
A. Sutherland et Cl. Willis, Synthesis of probes for the active site of leucine dehydrogenase, BIOORG MED, 9(14), 1999, pp. 1941-1944
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
14
Year of publication
1999
Pages
1941 - 1944
Database
ISI
SICI code
0960-894X(19990719)9:14<1941:SOPFTA>2.0.ZU;2-1
Abstract
A series of novel 3-substituted 2-oxobutanoic acids were prepared and incub ated with leucine dehydrogenase giving in one case both a kinetic resolutio n at C-3 and reductive amination of the ketone. This is the first example o f an amino acid dehydrogenase catalysed kinetic resolution and reductive am ination. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.