Isolation and structure of Sch 351633: A novel hepatitis C virus (HCV) NS3protease inhibitor from the fungus Penicillium griseofulvum

Authors
Chu, M Mierzwa, R He, L King, A Patel, M Pichardo, J Hart, A Butkiewicz, N Puar, MS
Citation
M. Chu et al., Isolation and structure of Sch 351633: A novel hepatitis C virus (HCV) NS3protease inhibitor from the fungus Penicillium griseofulvum, BIOORG MED, 9(14), 1999, pp. 1949-1952
Citations number
5
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
14
Year of publication
1999
Pages
1949 - 1952
Database
ISI
SICI code
0960-894X(19990719)9:14<1949:IASOS3>2.0.ZU;2-0
Abstract
A new hepatitis C virus (HCV) protease inhibitor designated as Sch 351633 ( 1) was isolated from the fungus, Penicillium griseofulvum. Structure elucid ation of 1 was accomplished by analysis of spectroscopic data, which determ ined compound 1 to be a bicyclic hemiketal lactone, compound 1 exhibited in hibitory activity in the HCV protease assay with an IC50 value of 3.8 mu g/ mL. (C) 1999 Elsevier Science Ltd. All rights reserved.