2,2-Dicyanovinyl as a nonaromatic aryl bioisostere: Synthesis, binding experiments and SAR studies of highly selective dopamine D4 receptor ligands

Authors
Haubmann, C Hubner, H Gmeiner, P
Citation
C. Haubmann et al., 2,2-Dicyanovinyl as a nonaromatic aryl bioisostere: Synthesis, binding experiments and SAR studies of highly selective dopamine D4 receptor ligands, BIOORG MED, 9(14), 1999, pp. 1969-1972
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
14
Year of publication
1999
Pages
1969 - 1972
Database
ISI
SICI code
0960-894X(19990719)9:14<1969:2AANAB>2.0.ZU;2-P
Abstract
The phenylpiperazinylmethyl substituted pyrrolylmethylenemalononitriles of type 3 and 4 were synthesized and evaluated as strong and selective dopamin e D4 receptor ligands. (C) 1999 Elsevier Science Ltd. All rights reserved.