The spiroketals containing a benzyloxymethyl moiety at C8 position showed the most potent apoptosis-inducing activity.

Authors
Mitsuhashi, S Shima, H Kawamura, T Kikuchi, K Oikawa, M Ichihara, A Oikawa, H
Citation
S. Mitsuhashi et al., The spiroketals containing a benzyloxymethyl moiety at C8 position showed the most potent apoptosis-inducing activity., BIOORG MED, 9(14), 1999, pp. 2007-2012
Citations number
8
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
14
Year of publication
1999
Pages
2007 - 2012
Database
ISI
SICI code
0960-894X(19990719)9:14<2007:TSCABM>2.0.ZU;2-A
Abstract
The spiroketals containing a benzyloxymethyl moiety at the C8 position show ed the most potent apoptosis-inducing activity, whereas its analogous compo unds lacking any substituent at C8 or possessing ones other than the benzyl oxymethyl moiety at C8 were all much less active, These results strongly su ggest an important role of the benzyloxymethyl moiety linked to the C8 oxyg en atom. (C) 1999 Elsevier Science Ltd. All rights reserved.