Synthesis and cytotoxicity of analogues of the antibiotic BE 10988 inhibitors of DNA topoisomerase II

Authors
Catrycke, MO Houssin, R Henichart, JP Pfeiffer, B Renard, P Dassonneville, L Bailly, C
Citation
Mo. Catrycke et al., Synthesis and cytotoxicity of analogues of the antibiotic BE 10988 inhibitors of DNA topoisomerase II, BIOORG MED, 9(14), 1999, pp. 2025-2030
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
14
Year of publication
1999
Pages
2025 - 2030
Database
ISI
SICI code
0960-894X(19990719)9:14<2025:SACOAO>2.0.ZU;2-E
Abstract
Indolequinone derivatives of the antitumour antibiotic BE 10988 were synthe sized and evaluated for their cytotoxicity and action mechanism. The quinon e system is essential to biological activity and the thiazole ring plays a major role in the poisoning of topoisomerase II. (C) 1999 Elsevier Science Ltd. All rights reserved.