Novel benzopyrano[3,4-c]pyrrole derivatives as potent and selective dopamine D-3 receptor antagonists

Authors
Dubuffet, T Newman-Tancredi, A Cussac, D Audinot, V Loutz, A Millan, MJ Lavielle, G
Citation
T. Dubuffet et al., Novel benzopyrano[3,4-c]pyrrole derivatives as potent and selective dopamine D-3 receptor antagonists, BIOORG MED, 9(14), 1999, pp. 2059-2064
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
14
Year of publication
1999
Pages
2059 - 2064
Database
ISI
SICI code
0960-894X(19990719)9:14<2059:NBDAPA>2.0.ZU;2-Y
Abstract
A new series of benzopyrano[3,4-c]pyrrole derivatives were synthesized and evaluated for their interaction with dopamine D-3 versus D-2 receptors. Amo ngst these compounds, 4x (S 33084) was found to be a potent and selective d opamine D-3 receptor antagonist. (C) 1999 Elsevier Science Ltd. All rights reserved.