P. Florio et al., Synthesis of Delta(4)-beta-D-glucopyranosiduronic acids as mimetics of 2,3-unsaturated sialic acids for sialidase inhibition, BIOORG MED, 9(14), 1999, pp. 2065-2068
Mimetics of Neu5Ac2en and KDN2en, based on Delta(4)-beta-D-glucopyranosidur
onic acids, have been synthesised. The Neu5Ac2en mimetic 5 showed inhibitio
n of both bacterial and viral sialidases, with inhibition of the viral sial
idase being comparable to that of Neu5Ac2en itself. (C) 1999 Published by E
lsevier Science Ltd. All rights reserved.