Synthesis of Delta(4)-beta-D-glucopyranosiduronic acids as mimetics of 2,3-unsaturated sialic acids for sialidase inhibition

Authors
Florio, P Thomson, RJ Alafaci, A Abo, S von Itzstein, M
Citation
P. Florio et al., Synthesis of Delta(4)-beta-D-glucopyranosiduronic acids as mimetics of 2,3-unsaturated sialic acids for sialidase inhibition, BIOORG MED, 9(14), 1999, pp. 2065-2068
Citations number
21
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
14
Year of publication
1999
Pages
2065 - 2068
Database
ISI
SICI code
0960-894X(19990719)9:14<2065:SODAAM>2.0.ZU;2-7
Abstract
Mimetics of Neu5Ac2en and KDN2en, based on Delta(4)-beta-D-glucopyranosidur onic acids, have been synthesised. The Neu5Ac2en mimetic 5 showed inhibitio n of both bacterial and viral sialidases, with inhibition of the viral sial idase being comparable to that of Neu5Ac2en itself. (C) 1999 Published by E lsevier Science Ltd. All rights reserved.