C32-O-Phenalkyl ether derivatives of the immunosuppressant ascomycin: a tether length study

Authors
Goulet, MT Sinclair, PT Wong, F Staruch, MJ Dumont, FJ Cryan, JG Wiederrecht, GJ Wyvratt, MJ Parsons, WH
Citation
Mt. Goulet et al., C32-O-Phenalkyl ether derivatives of the immunosuppressant ascomycin: a tether length study, BIOORG MED, 9(14), 1999, pp. 2085-2088
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
14
Year of publication
1999
Pages
2085 - 2088
Database
ISI
SICI code
0960-894X(19990719)9:14<2085:CEDOTI>2.0.ZU;2-Z
Abstract
A tether length study of C32-O-phenalkyl ether derivatives of ascomycin was conducted wherein it was determined that a 2-carbon tether provides optimu m in vitro immunosuppressive activity. Oxygen-bearing substituents along th e 2-carbon tether can further increase the potency of this design. (C) 1999 Elsevier Science Ltd. All rights reserved.