Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity.

Authors
Armstrong, HM Wong, F Holmes, MA Sinclair, PJ Goulet, MT Dumont, FJ Staruch, M Koprak, S Peterson, LB Rosa, R Wilusz, MB Wiederrecht, GJ Cryan, JG Wyvratt, MJ Parsons, WH
Citation
Hm. Armstrong et al., Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity., BIOORG MED, 9(14), 1999, pp. 2089-2094
Citations number
21
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
14
Year of publication
1999
Pages
2089 - 2094
Database
ISI
SICI code
0960-894X(19990719)9:14<2089:PICEDO>2.0.ZU;2-Z
Abstract
The synthesis of C32-O-arylethyl ether derivatives of ascomycin that posses s equivalent immunosuppressant activity but reduced toxicity, compared to F K-506, is described. (C) 1999 Elsevier Science Ltd. All rights reserved.