Tk. Vinh et al., 1-[(Benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles - potent competitive inhibitors of aromatase, BIOORG MED, 9(14), 1999, pp. 2105-2108
The synthesis of a series of novel 1-[(benzofuran-2-yl)phenylmethyl]-triazo
les and -tetrazoles is described. The compounds were tested for human place
ntal aromatase inhibition in vitro, using [1 beta-H-3]-androstenedione as t
he substrate for the aromatase enzyme, the percentage inhibition and IC50 d
ata is included. (C) 1999 Elsevier Science Ltd. All rights reserved.