Tetrapeptide derived inhibitors of complexation of a class II MHC: the peptide backbone is not inviolate

Authors
Jones, AB Acton, JJ Rivetna, MN Cummings, RT Cubbon, RM Nichols, EA Schwartz, CD Wicker, LS Hermes, JD
Citation
Ab. Jones et al., Tetrapeptide derived inhibitors of complexation of a class II MHC: the peptide backbone is not inviolate, BIOORG MED, 9(14), 1999, pp. 2109-2114
Citations number
21
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
14
Year of publication
1999
Pages
2109 - 2114
Database
ISI
SICI code
0960-894X(19990719)9:14<2109:TDIOCO>2.0.ZU;2-Y
Abstract
Major histocompatabilty (MHC) proteins rely heavily on peptide backbone rec ognition for ligation. Nonetheless, modifications to the polyamide backbone of a tetrapeptide ligand can be made without abrogating binding. (C) 1999 Elsevier Science Ltd. All rights reserved.