Y. Matsuoka et al., Kainic acid-induced inducible cyclooxygenase and c-Jun phosphorylation in the rat hippocampal formation, BRAIN RES, 836(1-2), 1999, pp. 213-217
inducible cyclooxygenase (COX-2) was transiently induced in the neurons thr
oughout the entire hippocampus between 6 and 24 h after injection of kainic
acid (KA). The induction of COX-2 correlated more closely with the inducti
on of c-Jun than with that of c-Fos. Phosphorylated c-Jun was induced 6-12
h after in the CA3 pyramidal neurons, which undergo apoptosis. Almost all o
f neurons with phosphorylated c-Jun were colocalized with COX-2. These resu
lts suggest that COX-2 and c-Jun phosphorylation may participate in KA-indu
ced neurodegeneration. (C) 1999 Elsevier Science B.V. All rights reserved.