P- and E-selectin-deficient mice are susceptible to cerebral ischemia-reperfusion injury

Authors
Soriano, SG Wang, YMF Wagner, DD Frenette, PS
Citation
Sg. Soriano et al., P- and E-selectin-deficient mice are susceptible to cerebral ischemia-reperfusion injury, BRAIN RES, 835(2), 1999, pp. 360-364
Citations number
25
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
835
Issue
2
Year of publication
1999
Pages
360 - 364
Database
ISI
SICI code
0006-8993(19990724)835:2<360:PAEMAS>2.0.ZU;2-2
Abstract
We examined brain sections from P- and E-selectin-deficient mice (-/-)and t heir nontransgenic littermates (+/+) after focal cerebral ischemia and repe rfusion (I/R) tissue injury. There was no difference in the subsequent infa rct volume after 3 h of ischemia and 21 h of reperfusion. These data indica te that selectin-independent mechanisms mediate tissue injury after a prolo nged period of transient focal ischemia. (C) 1999 Elsevier Science B.V. All rights reserved.