Incidence of corneal melting in association with systemic disease in the Yorkshire Region, 1995-7

Citation
M. Mckibbin et al., Incidence of corneal melting in association with systemic disease in the Yorkshire Region, 1995-7, BR J OPHTH, 83(8), 1999, pp. 941-943
Citations number
16
Categorie Soggetti
Optalmology,"da verificare
Journal title
BRITISH JOURNAL OF OPHTHALMOLOGY
ISSN journal
00071161 → ACNP
Volume
83
Issue
8
Year of publication
1999
Pages
941 - 943
Database
ISI
SICI code
0007-1161(199908)83:8<941:IOCMIA>2.0.ZU;2-U
Abstract
Aims-To estimate the incidence of corneal melting or necrotising keratitis in association with systemic disease in the Yorkshire Region and to determi ne the type and duration of the systemic association. Methods-In a prospective study, vigorous attempts were made to identify all patients presenting with newly diagnosed corneal melting over a 3 year per iod. Results-27 patients were identified during the study period. Rheumatoid art hritis and Wegener's granulomatosis were the most common disease associatio ns. Corneal melting was a late complication of rheumatoid arthritis, but us ually occurred during early and overt systemic disease in patients with Weg ener's granulomatosis. Conclusion-The annual incidence of corneal melting in the Yorkshire Region is 3.01/million/year (95% CI = 0.7-9.6).