The cases of six patients with pronounced, persistent, isolated gaze-e
voked orbicularis oculi myokymia (GEOM) discovered fortuitously are de
scribed. None had brain-stem lesions, and two had associated, unusual
cranial synkinesis (trigeminofacial, hypoglossal-facial, and spinal ac
cessory-facial). Additional features included asymmetric blinking and
pseudoblepharoclonus in a third patient and buccopharyngeal synkinesis
and post-deglutional tremors in a fourth. Ptosis and pupillary change
s were absent. With the possible exception of one case, GEOM seems to
be a congenital benign oculofacial synkinesis of brainstem origin.