Synthesis of 1-(5-amino-3,5-dideoxy-3-methoxycarbonylmethyl-beta-D-ribofuranosyl)thymine

Citation
Dm. Lu et al., Synthesis of 1-(5-amino-3,5-dideoxy-3-methoxycarbonylmethyl-beta-D-ribofuranosyl)thymine, CARBOHY RES, 317(1-4), 1999, pp. 193-197
Citations number
5
Categorie Soggetti
Agricultural Chemistry","Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
CARBOHYDRATE RESEARCH
ISSN journal
00086215 → ACNP
Volume
317
Issue
1-4
Year of publication
1999
Pages
193 - 197
Database
ISI
SICI code
0008-6215(19990430)317:1-4<193:SO1>2.0.ZU;2-A
Abstract
In order to synthesize amide-linked antisense oligonucleotides, a general c hemical approach was developed for the synthesis of building blocks in whic h an amino group and a carboxylic group are contained at the 5' and 3' posi tions of a nucleoside. (C) 1999 Elsevier Science Ltd. All rights reserved.