Asymmetric synthesis of the core cyclopentane of viridenomycin

Authors
Arrington, MP Meyers, AI
Citation
Mp. Arrington et Ai. Meyers, Asymmetric synthesis of the core cyclopentane of viridenomycin, CHEM COMMUN, (15), 1999, pp. 1371-1372
Citations number
10
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
15
Year of publication
1999
Pages
1371 - 1372
Database
ISI
SICI code
1359-7345(1999):15<1371:ASOTCC>2.0.ZU;2-Q
Abstract
The fully substituted cyclopentene ring with three stereogenic centers has been efficiently constructed for the first time using chiral bicyclic lacta ms, the insertion of the quaternary center being the key step; ring opening of chiral sulfates to the correct 1,2-dihydroxy substituents also played a major role in reaching 1 in suitable form (18) for further study.