Thiazolium-dependent catalytic antibodies produced using a covalent modification strategy

Authors
Tanaka, F Lerner, RA Barbas, CF
Citation
F. Tanaka et al., Thiazolium-dependent catalytic antibodies produced using a covalent modification strategy, CHEM COMMUN, (15), 1999, pp. 1383-1384
Citations number
23
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
15
Year of publication
1999
Pages
1383 - 1384
Database
ISI
SICI code
1359-7345(1999):15<1383:TCAPUA>2.0.ZU;2-R
Abstract
A thiazolium cofactor was introduced at a unique active site residue within antibodies that were generated by reactive immunization; the modified anti bodies catalyzed a new cofactor-dependent reaction.