alpha-beta structural transition of short oligopeptides by water/organic solvent titration

Authors
Sugimoto, N Zou, J Kazuta, H Miyoshi, D
Citation
N. Sugimoto et al., alpha-beta structural transition of short oligopeptides by water/organic solvent titration, CHEM LETT, (7), 1999, pp. 637-638
Citations number
16
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY LETTERS
ISSN journal
03667022 → ACNP
Issue
7
Year of publication
1999
Pages
637 - 638
Database
ISI
SICI code
0366-7022(199907):7<637:ASTOSO>2.0.ZU;2-1
Abstract
Designed two peptides, Ac-Trp-Lys-Ala(13)-Lys-NH2 and Ac-Trp-Lys-Ala(15)-Ly s-NH2 were synthesized by utilizing natural L-amino acids and were capable of performing a structural transition from beta-sheet to alpha-helix. The a lpha-beta transition of the designed peptides was induced by interstrand hy drophobic interaction. This shows that our designed peptides may be an mode l system for the elucidation of misfolding and transformation mechanism of pathogenic proteins.