Enantioselective synthesis of pyrrolydinonyl thymine nucleoside analogues

Enantioselective synthesis of a novel kind of optically active nucleoside a nalogues from natural malic acid is described. In the given nucleoside anal ogues the tetrahydrofuran ring is replaced by a pyrrolidinonyl ring bearing both a primary and a secondary hydroxy groups which could be useful for th e preparation of novel oligonucleotides. Assay of the prepared nucleoside a nalogues showed non-activity against virus.