This article examines the general principles of psychopharmacologic treatme
nt of obsessive-compulsive disorder (OCD) in children and adolescents. It i
ncludes a description of the currently approved medications for the treatme
nt of children and adolescents with OCD, their side effect profiles, approa
ches to refractory OCD, and a discussion of drug interactions. Future direc
tions for research are also considered.