Which T cells cause psoriasis?

Today, T cells appear to be the main protagonists in the pathogenesis of ps oriasis vulgaris. This article summarizes how T cells might contribute to t he generation of psoriatic skin lesions, It discusses the preferential T ce ll receptor usage and the putative mode of T cell activation in psoriatic s kin lesions, and how streptococcal throat infections could be involved in d isease manifestations. The results are integrated into a pathogenetic conce pt which considers psoriasis as a T-cell mediated autoimmune disorder.