Uncertainty and delay are common in the diagnosis of acute coronary syndrom
es (ACS). In the last 20 years, the need for faster, more accurate, and mor
e cost-effective diagnosis gave rise to the concept of specialized treatmen
t of patients with chest pain in emergency departments (EDs). The original
strategy dedicated a separate section of the ED and a nursing staff to the
task of rapid intervention in patients with acute myocardial infarction (MI
) and triage of low-risk patients. Chest pain centers grew quickly in popul
arity but evolved with a variety of goals, staffing plans, diagnostic resou
rces, and levels of commitment. Three existing centers-the University of Ci
ncinnati Heart ER, Brigham and Women's Hospital, and the Medical College of
Virginia-have implemented chest pain strategies with the common aims of (I
) screening for the entire spectrum of coronary artery disease, (2) avoidin
g unnecessary admissions, and (3) using multiple diagnostic modalities. Yet
, they differ in the specifics of their approaches and diagnostic methods (
e.g., echocardiography vs. treadmill vs, myocardial perfusion imaging). The
safety and cost effectiveness of these centers are discussed.