CRYOSURGERY OF PROSTATE-CANCER - USE OF ADJUVANT HORMONAL-THERAPY ANDTEMPERATURE MONITORING - A ONE-YEAR FOLLOW-UP

Objective: To determine the clinical outcomes at one year of Stages T2 -T3 prostate cancer by cryosurgery utilizing pretreatment with total a ndrogen ablation therapy and temperature monitoring to control the fre ezing process. Study Group: To date, 347 patients have had 356 cryosur gical procedures. 280 have reached one year post treatment Of these, 1 31 had re-evaluation with prostatic biopsy and serum PSA. Methods: Tra nsrectal ultrasound (TRUS) measurement of tumor size and biopsy of ext raprostatic space was used to stage patients into two main groups: con fined (66.6%) versus nonconfined (19.3%). Radiation failures (14.1%) f ormed a separate group. Failure rates for the 131 men include all canc er diagnosed during the one year period following cryosurgery. Results : The one year failure rate for the study group was 19.8% (26/131). Fo r stages T2a, T2b C, T3 and radiation failures, the rates of positive biopsies were 13.9%, 12.9%, 33.3% and 35%, respectively. For those wit h local control of cancer (negative biopsy), 80% had prostate specific antigen (PSA) levels of < 0.5 ng/ml. The statistical variables for pe rsistent cancer with prostate specific antigen > 0.5 ng/ml were: sensi tivity of 66.7%, PPV of 16.7%, NPV of 98% and specificity of 83.7%. A statistically significant difference exists between stages T2 vs T3 an d radiation failures (p = < 0.5). Major complications of rectal fistul a and total incontinence for previously non-treated cancer versus radi ation failures were 0.33% and 8.7% respectively a 26 times greater ris k. Conclusion: Results of cryosurgery for all stages of prostate cance r at one year are encouraging being 80% free of disease (biopsy and pr ostate specific antigen). The morbidity of the previously non-treated cancers from this procedure for us was minimal with high patient accep tance. For radiation failures a local control rate of 65% was achieved . However, early in our experience significant morbidity did occur and our enthusiasm for attempted salvage was initially tempered.