Intracerebral haemorrhage and cerebral amyloid angiopathy: CT features with pathological correlation

AIMS: To review the computed tomography (CT) features of intracerebral haem orrhage pathologically proven to be associated with cerebral amyloid angiop athy in order to facilitate recognition of the presence of cerebral amyloid angiopathy in life. METHODS: We prospectively collected the clinical and brain imaging records of patients dying following an intracerebral haemorrhage who underwent a po st-mortem examination and were found to have cerebral amyloid angiopathy, W e reviewed the brain imaging to highlight features of the haemorrhage and o f the rest of the brain common to these cases, RESULTS: Seven patients aged 60-86 gears were examined over a 30-month peri od, On CT, the notable features were that the haemorrhages appeared large, lobar, often extended through the cortex to the subarachnoid space or into the ventricles, and were multiple and recurrent in patients who survived th e initial bleed. The high density (blood) within the haematoma tended to se diment posteriorly, CONCLUSIONS: There are features on CT of cerebral amyloid angiopathy associ ated with spontaneous intracerebral haemorrhage which should raise the poss ibility of this underlying diagnosis. We suspect this condition is under-re cognized in life, and should perhaps be considered more widely.