A vital objective for second millennium biotechnology will be the enzymatic
conversion of renewable cellulosic biomass to inexpensive fermentable suga
rs; new and more efficient fermentation processes will convert this biologi
cal 'currency' to a variety of commodity products. Although early strides w
ill be made using process development and engineering disciplines, mid-term
and longer advances must rely heavily on insight gained through protein an
d metabolic engineering technologies. These challenging goats can be met mo
st effectively by the full integration of academic, federal, and industrial
efforts in teams that develop and apply new fundamental knowledge to key c
ost drivers.