Nonpeptidic ligands for peptide and protein receptors

The first potent nonpeptidic ligands for somatostatin, luteinizing hormone- releasing hormone, glucagon and bradykinin receptors have been reported. No npeptidic clinical candidates have been identified or are currently under s tudy for substance P, bradykinin, endothelin, growth hormone secretagogue, angiotensin, vasopressin, motilin and cholecystokinin. Design, screening, c ombinatorial chemistry and classical medicinal chemistry all played importa nt roles in these advances.