Novel strategies for pharmacotherapy of depression

Citation
Ka. Maubach et al., Novel strategies for pharmacotherapy of depression, CURR OP C B, 3(4), 1999, pp. 481-488
Citations number
65
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CURRENT OPINION IN CHEMICAL BIOLOGY
ISSN journal
13675931 → ACNP
Volume
3
Issue
4
Year of publication
1999
Pages
481 - 488
Database
ISI
SICI code
1367-5931(199908)3:4<481:NSFPOD>2.0.ZU;2-G
Abstract
Modulating monoamine activity as a therapeutic strategy continues to domina te antidepressant research, with a recent emphasis on agents with multiple targets, including combined serotonin/noradrenaline re-uptake inhibitors an d numerous serotonin receptor ligands. An important new development has bee n the emergence of potential novel mechanisms of action, notably modulation of the activity of neuropeptides substance P and corticotrophin-releasing factor, and the intracellular messenger cyclic adenosine monophosphate. Eff orts in this area have recently been rewarded by the demonstration of antid epressant efficacy of the substance P receptor antagonist MK-0869.