Host and viral genetics of chronic infection: a mouse model of gamma-herpesvirus pathogenesis

A general association of human and primate lymphotropic herpesviruses (gamm a-herpesviruses) with the development of lymphomas, as well as other tumors , especially in immunocompromised hosts, has been well documented. The lack of relevant small animal models for human gamma-herpesviruses has impeded progress in understanding the role of these viruses in the development of c hronic disease. Recent research characterizing infection of inbred strains of mice with a murine gamma-herpesvirus, gamma-herpesvirus 68 (gamma HV68), is providing insights into viral and host factors involved in the establis hment and control of chronic gamma-herpesvirus infection.