Multiple familial keratoacanthoma of Witten and Zak - A report of three siblings

Three out of 11 siblings of a nonconsanguineous marriage suffering from bio psy-proven multiple small eruptive keratoacanthoma (KA) of Grzybowski as we ll as large nodular KA of Ferguson-Smith are reported. The response to oral methotrexate was not encouraging. Intravenous 5-fluorouracil (5-FU) at a d ose of 12 mg/kg/day in isotonic saline given in weekly 5-day cycles resulte d in almost complete resolution of small eruptive lesions and signs of invo lution in older large agglomerate noduloulcerative KA after 6 cycles. Thus, intravenous 5-FU was found to be an effective therapeutic modality for the Witten and Zak type of KA.