DESIGN OF CONTROLLED CLINICAL-TRIALS FOR DIABETIC POLYNEUROPATHY

Diabetic neuropathy is a common and debilitating complication of diabe tes mellitus associated with high health costs, In recent years severa l clinical trials have been undertaken to test the efficacy of drug in tervention in this disorder, The results of these trials have in gener al been disappointing. In this review we discuss selection criteria, e fficacy endpoints, duration of clinical trials, and data collection an d analyses, We offer suggestions based on past experiences that might improve trial design and execution in order to achieve improved result s from treatment of this silent but common disorder.