Miniaturized FRET assays and microfluidics: key components for ultra-high-throughput screening

Authors
Mere, L Bennett, T Coassin, P England, P Hamman, B Rink, T Zimmerman, S Negulescu, P
Citation
L. Mere et al., Miniaturized FRET assays and microfluidics: key components for ultra-high-throughput screening, DRUG DISC T, 4(8), 1999, pp. 363-369
Citations number
7
Categorie Soggetti
Pharmacology & Toxicology
Journal title
DRUG DISCOVERY TODAY
ISSN journal
13596446 → ACNP
Volume
4
Issue
8
Year of publication
1999
Pages
363 - 369
Database
ISI
SICI code
1359-6446(199908)4:8<363:MFAAMK>2.0.ZU;2-C
Abstract
Assay miniaturization applicable across a wide range of target classes, alo ng with automation and process integration, are well-recognized goals for u lta-high-throughput screening on an industrial scale. This report summarize s the implementation of fluorescence resonance energy transfer (FRET)-based biochemical and cell-based assays in 3456-well NanoWell(TM) assay plates u sing key components of Aurora's ultra-high-throughput screening system.