Rothmund-Thomson syndrome with herpes encephalitis

A 4-year-old Japanese boy with Rothmund-Thomson syndrome suffered from seve re herpes encephalitis at 5 months of age. The serum level of immunoglobuli n G was low and the responsiveness of peripheral blood mononuclear cells to bacterial superantigens was poor. It was suggested that these immunologica l abnormalities, possibly associated with Rothmund-Thomson syndrome, led to severe infection with herpes simplex virus in our patient.