Systemic mastocytosis: MRI of bone marrow involvement

Citation
M. Roca et al., Systemic mastocytosis: MRI of bone marrow involvement, EUR RADIOL, 9(6), 1999, pp. 1094-1097
Citations number
25
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging
Journal title
EUROPEAN RADIOLOGY
ISSN journal
09387994 → ACNP
Volume
9
Issue
6
Year of publication
1999
Pages
1094 - 1097
Database
ISI
SICI code
0938-7994(1999)9:6<1094:SMMOBM>2.0.ZU;2-J
Abstract
Systemic mastocytosis (SM) is an abnormal proliferation of mast cells, loca ted in different structures: skin, bone marrow spleen, liver and lymph node s. Magnetic resonance imaging was prospectively, performed in ten patients diagnosed by bone marrow biopsy in order to describe the different patterns of bone marrow involvement. Coronal T1-weighted I spin-echo images were ob tained in vertebral, pelvic, humeral and femoral bones. Depending on the ex tension of the cell infiltration, three patterns of bone marrow involvement were used: normal/no involvement (N), non-homogeneous (NH) and homogeneous (H). All ten patients presented bone infiltration. The patterns observed w ere: spine (50 % NH, 50 % H), pelvis (70 % NH), humerus 100(NH) and femur 4 0 % (NH). T1-weighted MR imaging is a sensitive technique for detecting mar row abnormalities in patients with systemic mastocytosis. There is no corre lation between percentage of mast cells in bone marrow biopsy and extent or pattern of bone marrow involvement.