Patents on bacterial tRNA synthetase inhibitors: January 1996 to March 1999

Authors
Beaulieu, D Ohemeng, KA
Citation
D. Beaulieu et Ka. Ohemeng, Patents on bacterial tRNA synthetase inhibitors: January 1996 to March 1999, EXPERT OP T, 9(8), 1999, pp. 1021-1028
Citations number
39
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EXPERT OPINION ON THERAPEUTIC PATENTS
ISSN journal
13543776 → ACNP
Volume
9
Issue
8
Year of publication
1999
Pages
1021 - 1028
Database
ISI
SICI code
1354-3776(199908)9:8<1021:POBTSI>2.0.ZU;2-9
Abstract
This review focuses on patents published between January 1996 and March 199 9 covering bacterial tRNA synthetase inhibitors as antibacterial agents. Ni ne of the eleven patents issued during this period claim new formulations, forms and uses as well as new derivatives of pseudomonic acid A (mupirocin, SmitKline Beecham), a natural product inhibitor of isoleucyl-tRNA syntheta se. One patent describes a new use for indolmycin, an inhibitor of tryptoph anyl-tRNA synthetase, and another discloses a novel class of isoleucyl-tRNA synthetase inhibitors.