Ia. Parshikov et al., Regioselective transformation of ciprofloxacin to N-acetylciprofloxacin bythe fungus Mucor ramannianus, FEMS MICROB, 177(1), 1999, pp. 131-135
A strain of the saprobic fungus Mucor ramannianus, isolated from a forest,
was used to demonstrate the potential for ciprofloxacin biotransformation b
y zygomycetes in the environment. The fungus carried out the regioselective
N-acetylation of ciprofloxacin to a single product, which was purified fro
m culture extracts by high-performance liquid chromatography. The metabolit
e was identified by mass and nuclear magnetic resonance spectrometry as 1-c
yclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-acetyl-1-piperazinyl)-3-quinolin
ecarboxylic acid. (C) 1999 Federation of European Microbiological Societies
. Published by Elsevier Science B.V. All rights reserved.