Regioselective transformation of ciprofloxacin to N-acetylciprofloxacin bythe fungus Mucor ramannianus

Citation
Ia. Parshikov et al., Regioselective transformation of ciprofloxacin to N-acetylciprofloxacin bythe fungus Mucor ramannianus, FEMS MICROB, 177(1), 1999, pp. 131-135
Citations number
19
Categorie Soggetti
Microbiology
Journal title
FEMS MICROBIOLOGY LETTERS
ISSN journal
03781097 → ACNP
Volume
177
Issue
1
Year of publication
1999
Pages
131 - 135
Database
ISI
SICI code
0378-1097(19990801)177:1<131:RTOCTN>2.0.ZU;2-4
Abstract
A strain of the saprobic fungus Mucor ramannianus, isolated from a forest, was used to demonstrate the potential for ciprofloxacin biotransformation b y zygomycetes in the environment. The fungus carried out the regioselective N-acetylation of ciprofloxacin to a single product, which was purified fro m culture extracts by high-performance liquid chromatography. The metabolit e was identified by mass and nuclear magnetic resonance spectrometry as 1-c yclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-acetyl-1-piperazinyl)-3-quinolin ecarboxylic acid. (C) 1999 Federation of European Microbiological Societies . Published by Elsevier Science B.V. All rights reserved.