Prognostic importance of serial cytokine changes in ascites and pleural effusion in women with severe ovarian hyperstimulation syndrome

Citation
Cd. Chen et al., Prognostic importance of serial cytokine changes in ascites and pleural effusion in women with severe ovarian hyperstimulation syndrome, FERT STERIL, 72(2), 1999, pp. 286-292
Citations number
23
Categorie Soggetti
Reproductive Medicine","da verificare
Journal title
FERTILITY AND STERILITY
ISSN journal
00150282 → ACNP
Volume
72
Issue
2
Year of publication
1999
Pages
286 - 292
Database
ISI
SICI code
0015-0282(199908)72:2<286:PIOSCC>2.0.ZU;2-B
Abstract
Objective: To determine the prognostic value of various cytokine levels in ascites and pleural effusion during the evolution of severe ovarian hyperst imulation syndrome (OHSS). Design: A longitudinal study. Setting: University teaching hospital. Patient(s): Twenty patients with severe OHSS who required either paracentes is or thoracentesis or both from whom ascites (n = 56) or pleural effusion (n = 12) samples were obtained. Control peritoneal fluid was obtained from 20 patients undergoing ovarian stimulation for IVF. Intervention(s): Abdominal paracentesis for tense ascites and thoracentesis for massive pleural effusion. Control peritoneal fluid was obtained before oocyte retrieval. Main Outcome Measure(s): Levels of interleukin-1 beta (IL-1 beta), interleu kin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha) , vascular endothelial growth factor (VEGF), E-2, and progesterone concentr ations in ascites and pleural effusion. Result(s): Levels of VEGF and IL-6 in ascites dropped significantly during the course of OHSS and were not correlated with E-2 concentrations. Levels of VEGF were significantly correlated with levels of IL-1 beta, IL-8, and T NF-alpha, as well as progesterone concentrations, hematocrit, and white blo od cell counts. None of the cytokine levels measured in pleural effusion we re correlated with the course of OHSS. Conclusion(s): These results suggest that local cytokines might be involved in the evolution of severe OHSS and possibly serve as prognostic markers f or this syndrome. (C) 1999 by American Society for Reproductive Medicine.