An efficient synthesis of ofloxacin and levofloxacin from 3,4-difluoroaniline

Authors
Adrio, J Carretero, JC Ruano, JLG Pallares, A Vicioso, M
Citation
J. Adrio et al., An efficient synthesis of ofloxacin and levofloxacin from 3,4-difluoroaniline, HETEROCYCLE, 51(7), 1999, pp. 1563
Citations number
25
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
51
Issue
7
Year of publication
1999
Database
ISI
SICI code
0385-5414(19990701)51:7<1563:AESOOA>2.0.ZU;2-E
Abstract
The functionalization at either C-2 or C-3 of N-(tert-butoxycarbonyl)-3,4-d ifluoroaniline based on its ortho-deprotonation under different experimenta l conditions is described. This kind of products can be readily applied to the synthesis of ofloxacin, levofloxacin and related compounds.