Synthesis of cytotoxic pyrroloquinazolinoquinoline alkaloid luotonin A

Authors
Ma, ZZ Hano, Y Nomura, T Chen, YJ
Citation
Zz. Ma et al., Synthesis of cytotoxic pyrroloquinazolinoquinoline alkaloid luotonin A, HETEROCYCLE, 51(7), 1999, pp. 1593
Citations number
15
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
51
Issue
7
Year of publication
1999
Database
ISI
SICI code
0385-5414(19990701)51:7<1593:SOCPAL>2.0.ZU;2-P
Abstract
A convenient synthesis of cytotoxic pyrroloquinazolinoquinoline alkaloid, l uotonin A (1), was achieved in 3 steps; (i) reaction of anthranilic acid wi th O-methylbutyrolactim to deoxyvasicinone, (ii) oxidation of deoxyvasicino ne, and (iii) formation of luotonin A by the reaction of vasicinone with an thranyl aldehyde.