J. Maj et al., Effects of venlafaxine given repeatedly on alpha(1)-adrenergic, dopaminergic and serotonergic receptors in rat brain, HUM PSYCHOP, 14(5), 1999, pp. 333-344
Citations number
55
Categorie Soggetti
Neurosciences & Behavoir
Journal title
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
Venlafaxine (VEN), a representative of a new class of antidepressants (sero
tonin and noradrenaline reuptake inhibitors, SNRI), administered repeatedly
affects - as was demonstrated by us previously - the behavioural responsiv
eness of alpha(1)-adrenergic, dopaminergic (D-2 and D-3) and serotonergic s
ystems to their agonists. In the present study we aimed to find out whether
parallel changes in the binding to the respective receptors also occurred.
The experiment was carried out on male Wistar rats. VEN was administered i
n a dose of 10 mg/kg once or repeatedly (14 days, twice daily). The obtaine
d results showed that VEN did not change the binding (B-max and K-D) of alp
ha(1)-adrenergic receptors to [H-3]-prazosin in the cerebral cortex, having
increased only its displacement by phenylephrine. The binding (B-max and K
-D) to D-1 and D-2 receptors in the limbic forebrain and the striatum was n
ot affected by repeated venlafaxine when [H-3]-SCH 23390 and [H-3]-spiperon
e, respectively, were used as ligands. When [H-3]-quinpirole was used as a
ligand, the binding was enhanced in the striatum, the nucleus accumbens (sh
ell and core) and islands of Calleja. VEN also increased the binding of [H-
3]-7-OH-DPAT to D-3 receptors in islands of Calleja and the nucleus accumbe
ns (shell). In the serotonergic system, a decrease in the density of 5-HT1A
receptors was observed in the hippocampus, whereas no changes occurred in
the binding of 5-HT2 receptors in the cortex. Thus VEN given repeatedly enh
anced the binding (of the ligands that are agonists) to dopamine D-2 and D-
3 receptors. Weaker effects were observed in the alpha(1)-adrenergic and th
e serotonergic systems. Copyright (C) 1999 John Wiley & Sons, Ltd.