CD30 prevents T-cell responses to non-lymphoid tissues

Self antigens can induce T-cell tolerance via a mechanism termed cross-tole rance. This involves the transfer of peripheral tissue antigens to professi onal APC for presentation in the draining lymph nodes. In this site, CD8(+) T cells are activated, proliferate, and are slowly deleted by a CD95-depen dent mechanism. Prior to their deletion, some activated cells leave the lym ph nodes and encounter antigens on peripheral parenchymal tissues. Without functional CD30, these cells proliferate extensively and cause substantial tissue damage. Thus, CD30 limits autoreactivity, acting as a 'brake' on T-c ell proliferation after recognition of autoantigens on parenchymal tissues.