GPI-microdomains: a role in signalling via immunoreceptors

Authors
Horejsi, V Drbal, K Cebecauer, M Cerny, J Brdicka, T Angelisova, P Stockinger, H
Citation
V. Horejsi et al., GPI-microdomains: a role in signalling via immunoreceptors, IMMUNOL TOD, 20(8), 1999, pp. 356-361
Citations number
51
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
20
Issue
8
Year of publication
1999
Pages
356 - 361
Database
ISI
SICI code
0167-5699(199908)20:8<356:GARISV>2.0.ZU;2-B
Abstract
Glycosylphosphatidylinositol (GPI)-anchored proteins and glycosphingolipids are assembled on the leukocyte surface within membrane microdomains, which also accommodate a set of cytoplasmic signalling molecules (Src family kin ases, G-proteins, linker proteins). Recent results suggest that these membr ane specializations mediate not only signal transduction via GPI-proteins a nd glycolipids but also play important roles in initiation of signalling vi a immunoreceptors.