The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction

Authors
Lupher, ML Rao, N Eck, MJ Band, H
Citation
Ml. Lupher et al., The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction, IMMUNOL TOD, 20(8), 1999, pp. 375-382
Citations number
62
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
20
Issue
8
Year of publication
1999
Pages
375 - 382
Database
ISI
SICI code
0167-5699(199908)20:8<375:TCPANR>2.0.ZU;2-U
Abstract
The Cbl protooncoprotein has recently emerged as a component of tyrosine ki nase-mediated signal transduction in a variety of cell types. Here, we disc uss evidence that supports a role for Cbl as a novel negative regulator of immune receptor signaling, and present models for its mode of function.