Oxidative stress induced by exercise and dietary fat modulates the coenzyme Q and vitamin A balance between plasma and mitochondria

Physical exercise induces oxidative stress. Dietary fat modulates ii pid co mposition of plasma and fatty acid profile of mitochondrial membranes. Over 8 wk, two groups of rats were fed virgin olive oil or sunflower oil as the only fat sources, Both groups were divided into 4 subgroups according to e xercise: one of sedentary rats and the other three of rats subjected to dif ferent exercises on a treadmill. There was a lower concentration of vitamin A and coenzyme Q in the plasma of animals subjected to exercise compared t o the sedentary animals. The concentrations of these molecules in fiver and skeletal muscle mitochondria of animals exercised until exhaustion were hi gher than in sedentary animals, This can suggest the existence of a balance between plasma and mitochondrial membrane for these antioxidants as a resp onse to an oxidative attack.