Spatiotemporal pattern of the postnatal astrogliogenesis in the rat hippocampal formation

Newborn, 2-, 4-, 8-, 16- and 30-day-old Wistar rats were injected with 3H-t hymidine and sacrificed following 4 h. survival time. Brain sections contai ning the dorsal part of hippocampal formation were immunostained for S-100 beta protein and subjected to autoradiography to visualize proliferating as trocytes. Microscopical observations revealed age-dependent changes in the number and distribution of proliferating astrocytes. The changes were consi dered as being related to the neurogenetic gradient characteristic to the h ippocampal formation. (C) 1999 ISDN. Published by Elsevier Science Ltd. All rights reserved.