EFFECTS OF DIETARY SESAMINOL AND SESAMIN ON EICOSANOID PRODUCTION ANDIMMUNOGLOBULIN LEVEL IN RATS GIVEN ETHANOL

The effects of sesaminol and sesamin on the ethanol-induced modulation of immune indices related to food allergy were examined in rats given a low (10%)-casein diet, Chronic ethanol drinking, at the dietary lev el of 23% (w/w), significantly increased the plasma IgA and IgM concen trations, irrespective of the presence of 0.1% and 0.2% sesaminol, but the effects disappeared with 0.2% sesamin, A significant IgG-elevatin g effect of these lignans was also found, In contrast, the concentrati on of plasma IgE was not influenced by the dietary manipulation, Altho ugh ethanol drinking did not influence splenic leukotriene B-4 product ion, sesaminol tended to decrease it dose dependently, while sesamin i ncreased the plasma prostaglandin E-2 concentration, These results sug gest that sesaminol and sesamin seems to have a diverse effect on the plasma levels of immunoglobulins and eicosanoids.