Changes in physiological and biochemical indices during insect ontogenesisunder the influence of heavy metal salts

We studied growth and development of the domestic fly Musca domestica (stra in Cooper) during larvae growth on the substrate with introduced heavy meta ls acetates (Zn, Cu, Pb, and Cd) at various concentrations. Median lethal d ose (LD@50) was determined for Cu and Cd salts. Toxic concentrations of Cu and Cd decreased the weight, elongated larvae development, and affected ecd ysis and metamorphosis. We traced the changes in the activities of acid pho sphatase, monophenol monooxygenase, and nonspecific esterase during growth and development of the larvae, pupae, and imagoes. inhibiting effect of Cu and Cd salts on acid phosphatases and monophenol monooxygenase, respectivel y, was established in vivo. Median inhibition index (I-50) of the heavy met als was determined in vitro for the studied enzymes.