STIMULATING EFFECT OF ILEAL PANCREATICOBILIARY SECRETION ON ILEAL APOLIPOPROTEIN A-IV MESSENGER-RNA EXPRESSION IN FASTED RATS

The effect of pancreaticobiliary secretion on the intestinal expressio n of the apo A-IV gene was examined in fasted rats. Pancreaticobiliary diversion, but not biliary diversion alone, into the ileum increased the ileal apo A-IV mRNA expression by 24 h post-operation. Jejunal apo A-IV mRNA was reduced by biliary exclusion. The data suggest that the biliary constituent plays an important role in the apo A-IV gene expr ession in the entire length of the small intestine, and that up-regula tion of the apo A-IV gene requires exocrine pancreatic in addition to biliary secretion.