TMC-66, a new endothelin converting enzyme inhibitor produced by Streptomyces sp A5008

Authors
Asai, Y Nonaka, N Suzuki, SI Nishio, M Takahashi, K Shima, H Ohmori, K Ohnuki, T Komatsubara, S
Citation
Y. Asai et al., TMC-66, a new endothelin converting enzyme inhibitor produced by Streptomyces sp A5008, J ANTIBIOT, 52(7), 1999, pp. 607-612
Citations number
17
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820 → ACNP
Volume
52
Issue
7
Year of publication
1999
Pages
607 - 612
Database
ISI
SICI code
0021-8820(199907)52:7<607:TANECE>2.0.ZU;2-I
Abstract
A new endothelin converting enzyme (ECE) inhibitor, TMC-66 was isolated fro m the fermentation broth of Streptomyces sp. A5008. The structure of TMC-66 was elucidated by spectroscopic analyses to be a new member of benzo[a]nap hthacenequinone class of antibiotics. TMC-66 had a highly selective inhibit ory activity for ECE with an IC50 value of 2.9 mu M. Taxonomy of the produc ing strain is also described.