LOCALIZATION OF ALPHA BETA AND GAMMA/DELTA T-LYMPHOCYTES IN CRYPTOSPORIDIUM PARVUM-INFECTED TISSUES IN NAIVE AND IMMUNE CALVES/

Citation
Ms. Abrahamsen et al., LOCALIZATION OF ALPHA BETA AND GAMMA/DELTA T-LYMPHOCYTES IN CRYPTOSPORIDIUM PARVUM-INFECTED TISSUES IN NAIVE AND IMMUNE CALVES/, Infection and immunity, 65(6), 1997, pp. 2428-2433
Citations number
39
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
ISSN journal
00199567
Volume
65
Issue
6
Year of publication
1997
Pages
2428 - 2433
Database
ISI
SICI code
0019-9567(1997)65:6<2428:LOABAG>2.0.ZU;2-U
Abstract
The nature of the host's T-lymphocyte population within the intestinal villi following Cryptosporidium parvum infection was characterized wi th a bovine model of cryptosporidiosis. In naive animals, infection wi th C. parvum resulted in substantial increases in the numbers of alpha /beta T cells, both CD4(+) (150%) and CD8(+) (60%), and of gamma/delta T cells (70%) present within the intestinal villi of the infected ile um, In immune animals, the host T-lymphocyte response to a challenge i nfection with C. parvum was restricted to alpha/beta T cells, The numb er of CD4(+) T cells within the Peyer's patch of the ileum increased d ramatically; however, there a-as little change in the number or locali zation of CD4(+) T cells within the intestinal villi, In contrast, the number of CD8(+) T cells within the intestinal villi increased follow ing a challenge infection, In addition, the CD8(+) T cells were found to he intimately associated with the epithelial cells of the intestina l villi. The precise correlation between the accumulation of CD8(+) T cells and the normal site of parasite development suggests an importan t role for CD8(+) T cells in the immune animal.